Indole derivatives and their associated microbial genera are associated with the 1-year changes in cardiometabolic risk markers in Chinese adults

This study explores the role of indole metabolites, derived from gut microbiota, in cardiometabolic health among Chinese adults over one year. Key findings indicate that indole-3-propionic acid (IPA), indole-3-acetic acid (IAA), and indole-3-aldehyde (IAld) positively influence lipid profiles and arterial stiffness. However, IAld was associated with a decrease in HDL-C. The study identifies 18 bacterial genera contributing to IPA production and develops a microbial score predictive of cardiometabolic risk, suggesting a critical role for gut microbiota in metabolic health.

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