Cross-sectional analyses between the dietary index for gut microbiota and Parkinson’s disease in the middle-aged and elderly population

Using NHANES 2007–2020 data (n=17,373; age ≥40), PD cases identified by antiparkinsonian medication (n=232) had lower DI-GM scores. Higher DI-GM (≥6) was associated with a 49% reduction in PD prevalence, and restricted cubic spline models indicated a nonlinear inverse association. Findings were robust across demographic subgroups and sensitivity analyses. Implication: a gut-microbiota–friendly diet measured by DI-GM may be linked to lower PD risk and could inform diet-based prevention strategies.[117+ source]