This study evaluates the relationship between systemic immune-inflammation index (SII) and psoriasis prevalence using data from NHANES 2011–2014.
Key findings:
Higher SII was significantly associated with increased psoriasis risk (OR = 1.56; p = 0.0069).
The association was stronger in diabetics (OR = 3.40), overweight individuals (OR = 1.80), and middle-aged adults (40–59 years, OR = 1.98).
Receiver operating characteristic (ROC) curve analysis showed SII had a predictive value for psoriasis, especially in diabetic patients (AUC = 0.62).
Nonlinear relationships between SII and psoriasis were found in specific subgroups, including smokers and drinkers.
This study suggests SII as a novel biomarker for psoriasis risk assessment, particularly in high-risk populations.
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