Resource type:
Peer review
This mini‑review synthesizes evidence on how micronutrients modulate oxidative stress and inflammatory pathways in oral cancer. Deficiencies in zinc and selenium compromise SOD/GPX activity, while excess copper promotes fibrosis and angiogenesis; vitamins A, C, and E exhibit chemopreventive potential but require careful dosing to avoid pro‑oxidant effects. Vitamin D (via VDR signaling) and immunonutrition regimens (omega‑3s, arginine, nucleotides) show promise for improving treatment tolerance, lean mass, and immune function, though heterogeneity across formulations underscores the need for standardized, biomarker‑guided trials.