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This study explored how genetic risk, lifestyle factors, and diet interact to influence gastric cancer (GC) risk among Korean adults. High polygenic risk scores (PRSs) significantly increased GC risk, especially among smokers and those with low coffee or polyphenol intake. Genetic variant SEMA3C_rs1527482 was strongly linked to GC. Molecular docking analysis identified polyphenols like theaflavate and rugosin E as potential inhibitors of this variant. The findings suggest integrating genetic screening with personalized nutrition could mitigate GC risk.
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