This study investigates the relationship between lipid dysregulation, depression, and cognitive decline using two datasets:
A multigenerational familial risk study for Major Depressive Disorder (MDD) (n = 526).
The National Health and Nutrition Examination Survey (NHANES) (n = 2377).
Key Findings:
Depression was strongly linked to lipid imbalances, particularly decreased HDL and increased LDL levels.
Lipid dysregulation was associated with cognitive decline, particularly in those with metabolic diseases (e.g., diabetes, hypertension).
Depression mediated the relationship between HDL levels and cognitive function, suggesting mental health plays a key role in lipid-related neurocognitive decline.
The protective effect of HDL on cognition was absent in individuals with depression.
The study underscores the need for integrated lipid, mental health, and cognitive screening to prevent long-term decline.
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