This study investigates the relationship between systemic inflammation and MASLD, formerly known as non-alcoholic fatty liver disease (NAFLD). The study used NHANES 2017–2020 data, analyzing 6,613 adults for 10 inflammatory biomarkers, including C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR).
Key findings:
MASLD prevalence is rising due to obesity and metabolic disorders.
Certain inflammatory markers (ALI, CAR, PNI) were positively associated with MASLD risk, while NLR and PLR were negatively associated.
Subgroup analysis revealed that ALI had stronger associations in older adults.
Further studies are needed to explore the mechanistic link between inflammation and MASLD progression.
The study highlights inflammatory biomarkers as potential diagnostic tools for MASLD, warranting further clinical research.
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