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This study investigates the cytotoxic effects of amino-functionalized polystyrene nanoplastics (PS-NH2) on breast cancer (MDA-MB-231) and fibroblast (HFF-2) cells. Results indicate dose-dependent decreases in cell viability, induction of apoptosis, and cell cycle arrest in the G1 and sub-G1 phases. Smaller nanoparticle sizes and higher concentrations exacerbated oxidative stress, reducing superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities. The findings highlight the potential health risks of PS-NH2 exposure and its relevance in cancer treatment and environmental toxicity research.
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