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Summary: This assessment evaluates the safety of L-glutamine and L-glutamic acid in supplements, following requests from the Norwegian Food Safety Authority. The report concludes that the recommended doses for adults and adolescents do not pose significant health risks, though long-term safety studies are lacking. L-glutamine is deemed safe at doses up to 16,500 mg/day, and L-glutamic acid up to 5,500 mg/day, with a noted absence of adverse effects at these levels in short-term studies.