This paper outlines key research priorities in pediatric parenteral nutrition (PN), identified through a consensus approach by experts from ESPGHAN, ESPEN, ESPR, and CSPEN. The study ranks 99 research gaps in PN for neonates, infants, and children, aiming to guide future investigations and optimize clinical practices.
Key findings:
Top priority: Understanding the relationship between total energy intake, rapid catch-up growth, metabolic function, and neurocognitive outcomes.
Optimal macronutrient intake is crucial, but gaps remain in defining the best energy-protein ratio for preterm infants.
Need for multicenter trials to assess PN's impact on long-term metabolic and developmental health.
More data required on fluid, electrolyte, and micronutrient requirements, particularly in critically ill children.
Better monitoring tools and individualized PN strategies are needed to enhance clinical outcomes.
This research advocates for long-term studies and collaborative efforts to improve pediatric PN protocols.
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