This meta-analysis investigates the prognostic significance of the Controlling Nutritional Status (CONUT) score in patients with diffuse large B-cell lymphoma (DLBCL). By analyzing eight studies (2,687 patients), researchers examined the association between CONUT scores and survival outcomes (overall survival and progression-free survival).
Key findings:
High CONUT scores were significantly associated with poor overall survival (HR = 1.63, p < 0.001) and progression-free survival (HR = 1.22, p < 0.001).
Elevated CONUT scores correlated with adverse clinicopathological features, including advanced Ann Arbor stage (III-IV), extranodal disease, high ECOG performance status, and increased LDH levels.
Patients with higher CONUT scores had greater tumor burden and lower treatment response.
The findings suggest that nutritional status is a critical factor in DLBCL prognosis and may serve as a cost-effective biomarker for risk stratification.
This study supports the integration of CONUT scoring in clinical decision-making to improve DLBCL management and patient outcomes.
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