The Effect of Prebiotic Fiber on the Gut Microbiome and Surgical Outcomes in Patients with Prosthetic Joint Infection (PENGUIN Study) (2024)

By:
Deepti K. Sharma, Balamurugan Ramadass, Stuart A. Callary, Anthony Meade, Rishikesh Dash, Robyn Clothier, Gerald J. Atkins, L. Bogdan Solomon, Boopalan Ramasamy
Date:
2024
Resource type:
Blogs/news/opinion
Link:
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The PENGUIN study protocol outlines a randomized controlled trial to assess the impact of a prebiotic fiber supplement on gut microbiome health and surgical outcomes in patients with prosthetic joint infection (PJI) undergoing two-stage revision surgery. The trial will analyze gut microbiome profiles and inflammation markers in 80 patients receiving resistant starch versus a placebo. Findings from this study could inform preoperative dietary interventions to reduce infection recurrence and improve joint replacement outcomes.