The association of dietary choline intakes with cognitive function among the older people in underdeveloped regions: findings from the NCDFaC study

By:
Dan Liu, Yingying Niu, Haoyu Yan, Chengping Li, Lianhong Chen, Chenglian Li, Kui Dong, Zhihao Li, Jian Zhang, Zhuoqun Wang, Pengkun Song, Yanfang Zhao, Yi Zhai, Mei Zhang, Shaojie Pang, Shengquan Mi, Xiaofeng Liang, Shuang Song, Zhaoxue Yin, Wenhua Zhao
Date:
2025
Resource type:
Peer review
Link:
The association of dietary choline intakes with cognitive function among the ol…

In 1,522 Chinese adults ≥60 years (19.2% MCI), higher intake of total choline and key subtypes was associated with lower odds of mild cognitive impairment after multivariable adjustment and propensity score matching. Compared with the lowest quartile, ORs (95% CI) were 0.63 (0.42–0.94) for total choline Q2; for phosphatidylcholine Q2 and Q3, 0.59 (0.39–0.88) and 0.60 (0.40–0.91), respectively; and for free choline Q4, 0.55 (0.35–0.86). Results persisted post-PSM. Implication: moderate-to-high intakes of total choline, phosphatidylcholine, and free choline may be protective against MCI in resource-limited settings.[116+ source]