Alterations in Glucagon Levels and the Glucagon-to-Insulin Ratio in Response to High Dietary Fat or Protein Intake in Healthy Lean Adult Twins

This study explored how high-fat and high-protein diets affect glucagon levels and the glucagon-to-insulin ratio in healthy lean adult twins. Participants on a high-fat diet experienced significant increases in glucagon and the glucagon-to-insulin ratio, while insulin resistance slightly increased. A subsequent high-protein diet further elevated glucagon levels. These findings suggest glucagon may play a role in preventing liver fat accumulation in response to dietary fat and protein intake.

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