This cross-sectional study assessed how diet, physical activity, and sleep influence resting energy expenditure (REE) in 75 healthy adults aged 30–45 without obesity. Using indirect calorimetry, bioelectrical impedance analysis, and accelerometers, the study found that fat-free mass (FFM) had the strongest association with REE. Moderate physical activity (MPA) and HDL cholesterol also showed significant positive associations with REE, independent of FFM and sex. Other factors (HOMA-IR, triglycerides, insulin) were linked to REE in unadjusted models but lost significance after controlling for body composition. Sleep duration showed no significant effect. The findings highlight MPA and HDL-C as key lifestyle-linked influencers of REE, potentially contributing to cardiometabolic disease prevention.
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